Covalent drugs block protein function by forming a specific bond between the ligand and target protein. A covalent mechanism of action can provide many pharmacological advantages over a reversible ...
A structure of the drug ibrutinib. The drug ibrutinib makes a covalent bond to Bruton's tyrosine kinase, an important cancer target. Credit: RCSB PDB/Yang H. Ku Enticing atoms to share their electrons ...
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