系统性硬化症（Systemic sclerosis，SSc），常被称为“硬皮病”，是一种罕见的慢性自身免疫性疾病。它远非简单的皮肤病变，而是以免疫系统紊乱、微血管病变及多器官进行性纤维化为特征，被称为“人体内的水泥病”。 患者皮肤逐渐硬化、紧绷，关节活动受限，更严重的是，肺、心脏、消化道等内脏器官也会因异常纤维化而功能受损，威胁生命。 全球数据显示，该病患病率约为每百万人口50-300例，且女性发 ...

Systemic sclerosis is a complex autoimmune condition marked by aberrant immune activation, widespread fibrosis and vasculopathy that affect the skin and multiple internal organs. The disease manifests ...

Patients with scleroderma renal crisis demonstrated specific enrichment of CD14+ monocytes with increased EGR1 expression and activation of NF-κB–related pathways. Trajectory analysis indicated that ...

Mycophenolate mofetil treatment in patients with limited cutaneous systemic sclerosis is linked to a reduced need for escalation of vasoactive or vasodilator therapies for vascular complications.

Calcinosis cutis, a debilitating deposition of calcium salts in the skin and subcutaneous tissues, is a frequent and challenging complication in patients with systemic sclerosis and other connective ...

Opportunities lie in strategic investment formulation, identifying cost-effective locations for conducting trials, understanding global trial trends, and analyzing trial success rates. Insights into ...

The scleroderma skin pinch test checks the thickness and elasticity of your skin. It can help doctors diagnose and monitor scleroderma, an autoimmune condition that causes inflammation and thickening ...

The VEDOSS project has previously shown that 70% of patients with Raynaud's phenomenon and at least one red flag – systemic sclerosis (SSc)-specific antibodies, puffy fingers, or an SSc pattern on ...

A nationwide Swedish register-based study revealed that individuals with systemic sclerosis had a higher risk for hematologic malignancies. Myeloid malignancies typically presented around disease ...

Episodes of Raynaud's phenomenon, a common feature of systemic sclerosis (SSc, also known as scleroderma), were more severe not only at low temperatures, as one would expect, but also during ...

The "Systemic Scleroderma Treatment Market Share, Size, Trends, Industry Analysis Report, By Drug Class; By Regions; Segment Forecast, 2021-2028" report has been added to ResearchAndMarkets.com’s ...