Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular ...

Mitochondria are essential organelles that drive energy production, regulate apoptosis and orchestrate metabolic signalling within cells. Their dynamic nature underpins processes as diverse as ATP ...

Deferiprone（去铁酮，AbMole，M2617）作为一种铁螯合剂，在调控铁代谢和抑制铁死亡（Ferroptosis）方面展现出显著的研究价值。其作用机制主要通过调节铁稳态和抗氧化途径实现，Deferiprone（DFP，AbMole，M26 ...

Pretzel Therapeutics is advancing its mitochondrial disease therapies, pushing lead candidate PX578 through Phase 1 trials ...

Area of Focus: mitochondrial quality control, cellular metabolism, immune responses and the mechanisms underlying neurodegenerative diseases. Fourteen years ago, Xin Qi joined the Department of ...

Prof. Ciro Leonardo Pierri's expertise in structural biology, mitochondrial carrier modeling, and drug targeting—demonstrated ...

Researchers have identified a metabolically sensitive cell subtype in the eye's drainage system which shows early signs of ...

Mitochondrial respiratory complexes (Complexes I–V) and their assembly into respiratory supercomplexes (SCs) are fundamental to liver bioenergetics, redox homeostasis, and metabolic adaptability.

Metabolic syndrome refers to having multiple conditions that increase the risk of health problems like diabetes, stroke and heart disease.Photograph: koto_feja/Getty Images Metabolic syndrome refers ...