Gene therapy vectors based on gamma-retroviruses, lentiviruses and adeno-associated virus integrate into the genome of transduced cells with different efficiency and integration site selection 1,2,3,4 ...

A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...